RapamycinFungusV1, Main, Exploration, bibRecord, 000231

Spatially Distinct Pools of TORC1 Balance Protein Homeostasis.

Identifieur interne : 000231 ( Main/Exploration ); précédent : 000230; suivant : 000232

Spatially Distinct Pools of TORC1 Balance Protein Homeostasis.

Auteurs : Riko Hatakeyama [Suisse] ; Marie-Pierre Péli-Gulli [Suisse] ; Zehan Hu [Suisse] ; Malika Jaquenoud [Suisse] ; Guillermo Miguel Garcia Osuna [Suisse] ; Alessandro Sardu [Suisse] ; Jörn Dengjel [Allemagne] ; Claudio De Virgilio [Suisse]

Source :

Molecular cell [ 1097-4164 ] ; 2019.

RBID : pubmed:30527664

Descripteurs français

English descriptors

Abstract

The eukaryotic TORC1 kinase is a homeostatic controller of growth that integrates nutritional cues and mediates signals primarily from the surface of lysosomes or vacuoles. Amino acids activate TORC1 via the Rag GTPases that combine into structurally conserved multi-protein complexes such as the EGO complex (EGOC) in yeast. Here we show that Ego1, which mediates membrane-anchoring of EGOC via lipid modifications that it acquires while traveling through the trans-Golgi network, is separately sorted to vacuoles and perivacuolar endosomes. At both surfaces, it assembles EGOCs, which regulate spatially distinct pools of TORC1 that impinge on functionally divergent effectors: vacuolar TORC1 predominantly targets Sch9 to promote protein synthesis, whereas endosomal TORC1 phosphorylates Atg13 and Vps27 to inhibit macroautophagy and ESCRT-driven microautophagy, respectively. Thus, the coordination of three key regulatory nodes in protein synthesis and degradation critically relies on a division of labor between spatially sequestered populations of TORC1.

DOI: 10.1016/j.molcel.2018.10.040
PubMed: 30527664

Affiliations:

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<term>Adaptor Proteins, Signal Transducing (metabolism)</term>
<term>Autophagy (MeSH)</term>
<term>Autophagy-Related Proteins (genetics)</term>
<term>Autophagy-Related Proteins (metabolism)</term>
<term>Endosomal Sorting Complexes Required for Transport (genetics)</term>
<term>Endosomal Sorting Complexes Required for Transport (metabolism)</term>
<term>Endosomes (enzymology)</term>
<term>Endosomes (genetics)</term>
<term>Gene Expression Regulation, Fungal (MeSH)</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Protein-Serine-Threonine Kinases (metabolism)</term>
<term>Proteolysis (MeSH)</term>
<term>Proteostasis (MeSH)</term>
<term>Saccharomyces cerevisiae (enzymology)</term>
<term>Saccharomyces cerevisiae (genetics)</term>
<term>Saccharomyces cerevisiae Proteins (genetics)</term>
<term>Saccharomyces cerevisiae Proteins (metabolism)</term>
<term>Signal Transduction (MeSH)</term>
<term>Transcription Factors (genetics)</term>
<term>Transcription Factors (metabolism)</term>
<term>Vacuoles (enzymology)</term>
<term>Vacuoles (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Autophagie (MeSH)</term>
<term>Complexes de tri endosomique requis pour le transport (génétique)</term>
<term>Complexes de tri endosomique requis pour le transport (métabolisme)</term>
<term>Endosomes (enzymologie)</term>
<term>Endosomes (génétique)</term>
<term>Facteurs de transcription (génétique)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Homéostasie protéique (MeSH)</term>
<term>Protein-Serine-Threonine Kinases (génétique)</term>
<term>Protein-Serine-Threonine Kinases (métabolisme)</term>
<term>Protéines adaptatrices de la transduction du signal (génétique)</term>
<term>Protéines adaptatrices de la transduction du signal (métabolisme)</term>
<term>Protéines associées à l'autophagie (génétique)</term>
<term>Protéines associées à l'autophagie (métabolisme)</term>
<term>Protéines de Saccharomyces cerevisiae (génétique)</term>
<term>Protéines de Saccharomyces cerevisiae (métabolisme)</term>
<term>Protéolyse (MeSH)</term>
<term>Régulation de l'expression des gènes fongiques (MeSH)</term>
<term>Saccharomyces cerevisiae (enzymologie)</term>
<term>Saccharomyces cerevisiae (génétique)</term>
<term>Transduction du signal (MeSH)</term>
<term>Vacuoles (enzymologie)</term>
<term>Vacuoles (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term>
<term>Autophagy-Related Proteins</term>
<term>Endosomal Sorting Complexes Required for Transport</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term>
<term>Autophagy-Related Proteins</term>
<term>Endosomal Sorting Complexes Required for Transport</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Endosomes</term>
<term>Saccharomyces cerevisiae</term>
<term>Vacuoles</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Endosomes</term>
<term>Saccharomyces cerevisiae</term>
<term>Vacuoles</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Endosomes</term>
<term>Saccharomyces cerevisiae</term>
<term>Vacuoles</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Complexes de tri endosomique requis pour le transport</term>
<term>Endosomes</term>
<term>Facteurs de transcription</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines adaptatrices de la transduction du signal</term>
<term>Protéines associées à l'autophagie</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Saccharomyces cerevisiae</term>
<term>Vacuoles</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Complexes de tri endosomique requis pour le transport</term>
<term>Facteurs de transcription</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines adaptatrices de la transduction du signal</term>
<term>Protéines associées à l'autophagie</term>
<term>Protéines de Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Autophagy</term>
<term>Gene Expression Regulation, Fungal</term>
<term>Proteolysis</term>
<term>Proteostasis</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Autophagie</term>
<term>Homéostasie protéique</term>
<term>Protéolyse</term>
<term>Régulation de l'expression des gènes fongiques</term>
<term>Transduction du signal</term>
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<front><div type="abstract" xml:lang="en">The eukaryotic TORC1 kinase is a homeostatic controller of growth that integrates nutritional cues and mediates signals primarily from the surface of lysosomes or vacuoles. Amino acids activate TORC1 via the Rag GTPases that combine into structurally conserved multi-protein complexes such as the EGO complex (EGOC) in yeast. Here we show that Ego1, which mediates membrane-anchoring of EGOC via lipid modifications that it acquires while traveling through the trans-Golgi network, is separately sorted to vacuoles and perivacuolar endosomes. At both surfaces, it assembles EGOCs, which regulate spatially distinct pools of TORC1 that impinge on functionally divergent effectors: vacuolar TORC1 predominantly targets Sch9 to promote protein synthesis, whereas endosomal TORC1 phosphorylates Atg13 and Vps27 to inhibit macroautophagy and ESCRT-driven microautophagy, respectively. Thus, the coordination of three key regulatory nodes in protein synthesis and degradation critically relies on a division of labor between spatially sequestered populations of TORC1.</div>
</front>
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<Month>05</Month>
<Day>28</Day>
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<Month>05</Month>
<Day>28</Day>
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<Issue>2</Issue>
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<Month>01</Month>
<Day>17</Day>
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<Title>Molecular cell</Title>
<ISOAbbreviation>Mol Cell</ISOAbbreviation>
</Journal>
<ArticleTitle>Spatially Distinct Pools of TORC1 Balance Protein Homeostasis.</ArticleTitle>
<Pagination><MedlinePgn>325-338.e8</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.molcel.2018.10.040</ELocationID>
<Abstract><AbstractText>The eukaryotic TORC1 kinase is a homeostatic controller of growth that integrates nutritional cues and mediates signals primarily from the surface of lysosomes or vacuoles. Amino acids activate TORC1 via the Rag GTPases that combine into structurally conserved multi-protein complexes such as the EGO complex (EGOC) in yeast. Here we show that Ego1, which mediates membrane-anchoring of EGOC via lipid modifications that it acquires while traveling through the trans-Golgi network, is separately sorted to vacuoles and perivacuolar endosomes. At both surfaces, it assembles EGOCs, which regulate spatially distinct pools of TORC1 that impinge on functionally divergent effectors: vacuolar TORC1 predominantly targets Sch9 to promote protein synthesis, whereas endosomal TORC1 phosphorylates Atg13 and Vps27 to inhibit macroautophagy and ESCRT-driven microautophagy, respectively. Thus, the coordination of three key regulatory nodes in protein synthesis and degradation critically relies on a division of labor between spatially sequestered populations of TORC1.</AbstractText>
<CopyrightInformation>Copyright © 2018 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hatakeyama</LastName>
<ForeName>Riko</ForeName>
<Initials>R</Initials>
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</AffiliationInfo>
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<ForeName>Marie-Pierre</ForeName>
<Initials>MP</Initials>
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<ForeName>Zehan</ForeName>
<Initials>Z</Initials>
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</AffiliationInfo>
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<ForeName>Malika</ForeName>
<Initials>M</Initials>
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</AffiliationInfo>
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<ForeName>Alessandro</ForeName>
<Initials>A</Initials>
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<ForeName>Claudio</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Biology, University of Fribourg, 1700 Fribourg, Switzerland. Electronic address: claudio.devirgilio@unifr.ch.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>12</Month>
<Day>06</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mol Cell</MedlineTA>
<NlmUniqueID>9802571</NlmUniqueID>
<ISSNLinking>1097-2765</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C413216">ATG13 protein, S cerevisiae</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D048868">Adaptor Proteins, Signal Transducing</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000071183">Autophagy-Related Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D056827">Endosomal Sorting Complexes Required for Transport</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C501979">MEH1 protein, S cerevisiae</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C561842">TORC1 protein complex, S cerevisiae</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C119627">VPS27 protein, S cerevisiae</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="C530964">SCH9 protein, S cerevisiae</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Autophagy. 2019 Apr;15(4):561-564</RefSource>
<PMID Version="1">30696339</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>Autophagy. 2019 May;15(5):915-916</RefSource>
<PMID Version="1">30732525</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D048868" MajorTopicYN="N">Adaptor Proteins, Signal Transducing</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000071183" MajorTopicYN="N">Autophagy-Related Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D056827" MajorTopicYN="N">Endosomal Sorting Complexes Required for Transport</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011992" MajorTopicYN="N">Endosomes</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015966" MajorTopicYN="N">Gene Expression Regulation, Fungal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017346" MajorTopicYN="N">Protein-Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059748" MajorTopicYN="N">Proteolysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000074702" MajorTopicYN="Y">Proteostasis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014617" MajorTopicYN="N">Vacuoles</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Atg13</Keyword>
<Keyword MajorTopicYN="Y">ESCRT</Keyword>
<Keyword MajorTopicYN="Y">Rag GTPases</Keyword>
<Keyword MajorTopicYN="Y">TORC1</Keyword>
<Keyword MajorTopicYN="Y">Vps27</Keyword>
<Keyword MajorTopicYN="Y">amino acid signaling</Keyword>
<Keyword MajorTopicYN="Y">endosomal sorting complex required for transport</Keyword>
<Keyword MajorTopicYN="Y">growth control</Keyword>
<Keyword MajorTopicYN="Y">macroautophagy</Keyword>
<Keyword MajorTopicYN="Y">microautophagy</Keyword>
<Keyword MajorTopicYN="Y">protein homeostasis</Keyword>
<Keyword MajorTopicYN="Y">target of rapamycin complex 1</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>07</Month>
<Day>30</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2018</Year>
<Month>10</Month>
<Day>03</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>10</Month>
<Day>25</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>12</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>5</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>12</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">30527664</ArticleId>
<ArticleId IdType="pii">S1097-2765(18)30934-1</ArticleId>
<ArticleId IdType="doi">10.1016/j.molcel.2018.10.040</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Allemagne</li>
<li>Suisse</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>Canton de Fribourg</li>
<li>District de Fribourg-en-Brisgau</li>
</region>
<settlement><li>Fribourg</li>
<li>Fribourg-en-Brisgau</li>
</settlement>
<orgName><li>Université de Fribourg</li>
</orgName>
</list>
<tree><country name="Suisse"><region name="Canton de Fribourg"><name sortKey="Hatakeyama, Riko" sort="Hatakeyama, Riko" uniqKey="Hatakeyama R" first="Riko" last="Hatakeyama">Riko Hatakeyama</name>
</region>
<name sortKey="De Virgilio, Claudio" sort="De Virgilio, Claudio" uniqKey="De Virgilio C" first="Claudio" last="De Virgilio">Claudio De Virgilio</name>
<name sortKey="Garcia Osuna, Guillermo Miguel" sort="Garcia Osuna, Guillermo Miguel" uniqKey="Garcia Osuna G" first="Guillermo Miguel" last="Garcia Osuna">Guillermo Miguel Garcia Osuna</name>
<name sortKey="Hu, Zehan" sort="Hu, Zehan" uniqKey="Hu Z" first="Zehan" last="Hu">Zehan Hu</name>
<name sortKey="Jaquenoud, Malika" sort="Jaquenoud, Malika" uniqKey="Jaquenoud M" first="Malika" last="Jaquenoud">Malika Jaquenoud</name>
<name sortKey="Peli Gulli, Marie Pierre" sort="Peli Gulli, Marie Pierre" uniqKey="Peli Gulli M" first="Marie-Pierre" last="Péli-Gulli">Marie-Pierre Péli-Gulli</name>
<name sortKey="Sardu, Alessandro" sort="Sardu, Alessandro" uniqKey="Sardu A" first="Alessandro" last="Sardu">Alessandro Sardu</name>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Dengjel, Jorn" sort="Dengjel, Jorn" uniqKey="Dengjel J" first="Jörn" last="Dengjel">Jörn Dengjel</name>
</region>
</country>
</tree>
</affiliations>
</record>

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	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

Spatially Distinct Pools of TORC1 Balance Protein Homeostasis.

Spatially Distinct Pools of TORC1 Balance Protein Homeostasis.

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